The KLOCD database was created and maintained by Professor Gu Zhongze's team at KLOCD. Professor Gu Zhongze (recipient of the National Outstanding Youth Fund, head of the Innovation Team of the Ministry of Education, leader of the 111 Talent Introduction Program, Fellow of the American Academy of Medical and Biological Engineering, and Fellow of the Royal Society of Chemistry) has been engaged in organ chip research for a long time. He has successfully developed 14 important organ chips, including liver chips, tumor chips, heart chips, and brain chips, and is committed to promoting the standard setting and industry development of organ chips in China. Recently, the first national standard for organ chips led by the team, GB/T 44831-2024 "General Technical Requirements for Skin Chips", was released, marking substantial progress in domestic organ chip research. In addition, relying on the National Key Laboratory of Digital Medical Engineering, we can obtain first-hand scientific research materials and cutting-edge information.

Organ chip is a scientific technology with the main feature of manipulating fluids in micron-scale space. Organ chips have been regarded as a very important emerging scientific and technological platform and a strategic field of industrial transformation at the national level. The organ chip was named one of the world's "Top 10 Emerging Technologies" in 2016 by the World Economic Forum (Davos Forum). At present, the mainstream form of microfluidic chip refers to the integration or basic integration of basic operation units such as sample preparation, reaction, separation, detection, cell culture, sorting, and lysis in the fields of chemistry and biology. On a centimeter or smaller chip, a network of micro channels forms a controlled fluid throughout the system, a technology used to realize various functions of different laboratories in conventional chemistry, biology, materials, optics, etc. The basic characteristics and biggest advantages of the microfluidic chip laboratory are the flexible combination and scale integration of multiple unit technologies on a tiny platform that can be controlled overall. The human organ chip can provide a model similar to the human environment for medical, pharmaceutical and life science research, as well as data for alternative animals and clinical experiments for drug development and screening, disease model construction and other studies.<br/>The data generated by organ chips is currently in the early stages of a "surge", and maintaining relevant data is crucial for the development of the industry. In addition, with the technological suppression and blockade of China by Western countries such as the United States, it is urgent to establish our own database system. Therefore, it is necessary to establish the China National Organ Chip Science Data Center at the appropriate time.

Knowledge Graph & Large Language Model-Enhanced Organ on a Chip Database (KLOCD) is a unified platform (Science as a Service) that provides organ chip biological big data sharing and application services for scientific research communities. It is based on big data, artificial intelligence and Cloud computing technology provides data services specifically for organ chip data archiving, computational analysis, knowledge search, sharing services, and visualization. KLOCD currently integrates data from its own laboratory data, registered collaborator data, and published public data, including published academic literature, patents, and public database data. KLOCD organizes, archives, annotates, analyzes and visualizes these data, and finally forms: projects, tissues and organs, cell types, organ chip devices, technology, disease models, drugs and poisons, brain organs special library, online analysis More than 10 sub-databases and modules such as models and tools, visual display, standardization, and academic community communication. KLOCD searches and builds an index, and correlates these data with organ tissue and drug, poison and disease model research, so as to realize the traceability of the entire process of organ chip data from specific organization to project research to information data to achieve comprehensive data. More importantly, our database is updated in real time to complete the latest academic papers and related information updates, and to provide the latest progress in the field of organ chip research, research hotspot analysis, real-time online statistics in academic related fields, for global organ chips Researchers and experts in the fields of industry and government health medicine provide the most comprehensive, real-time and dynamic progress in the latest organ chip research. Our database provides data foundation and analysis tools for scientific research, industrial application, and standardization of organ chip technology.

KLOCD data archiving, data search, data calculation, scientific database and other external service data sources mainly come from NCBI, EBI, OpenFDA, TogoWS, UniChem, DrugBank, ChEMBL, clinicaltrials.gov, ctti-clinicaltrials.org, NAMCS / NHAMCS, TOXNET, Public data of GTEx and other databases. We sincerely thank these databases for providing us with rich biomedical data resources, and sincerely thank them for their contributions to the cause of biological data archiving and sharing. KLOCD has no special restrictions on the use of these public data resources. However, these data are subject to the terms and conditions of these external databases. Before using these external databases to disclose data, please review the specific terms and conditions of each database to be used to ensure compliance with all applicable regulations. All public data and data services provided by KLOCD are free for users worldwide.